This includes:

1. Microorganisms.
2. Human and non-human primate derived materials which may contain human pathogens (e.g. blood, fluids, tissues, organs, primary and established cell lines, etc.).
3. Biotoxins with an LD50 of less than 100 micrograms per kilogram of body weight in vertebrates.
4. Recombinant or Synthetic Nucleic Acid Molecule activities as described in the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules (includes human gene transfer).
5. Select Agents or Toxins as defined by CDC (42 CFR 73) or USDA (9 CFR 121 or 7 CFR 331).