This includes:

1. Microorganisms;
2. Human and non-human primate derived materials which may contain human pathogens (e.g. blood, fluids, tissues, organs, primary and established cell lines, etc.);
3. Biotoxins with an LD50 of less than 100 micrograms per kilogram of body weight in vertebrates;
4. Recombinant or Synthetic Nucleic Acid Molecule activities as described in the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules (includes human gene transfer); and
5. Select Agents or Toxins as defined by CDC (42 CFR 73) or USDA (9 CFR 121 or 7 CFR 331).